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KMID : 0616120190500010025
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 1 p.25 ~ p.31
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In vivo Screening of Herbal Extracts on High Glucose-induced Changes in Hyaloid-Retinal Vessels of Zebrafish
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Lee Yu-Ri
Jung Seung-Hyun
Lee Ik-Soo
Kim Joo-Hwan
Kim Young-Sook
Kim Jin-Sook
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Abstract
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The zebrafish (Danio rerio) is an established model organism for several pathophysiological conditions which are related to human diseases. In this study, we tested the preventive effect of eight herbal extracts, which show the inhibitory effect of advanced glycation end products (AGEs) or aldose reductase (AR) in our previous study, on high glucose (HG)-induced retinal vessel dilation in larval zebrafish and analyzed the change of hyaloid vasculature. HG-induced zebrafish hyaloid vasculatures were significantly increased in the thickness compared to untreated zebrafish (P<0.001, n=6~10). Eight herbal extracts were found to have significant retinal vessel dilation on the inhibitory activity. Particularly, Brandisia hancei (twigs and fruits), Castanopsis orthacantha (leaves and twigs), Litsea japonica (leaves and twigs), Spenceria ramalana (whole plant), and Synedrella nodiflora (leaves and stems) showed potent inhibitory activity against retinal vessel dilation in HG-induced larval zebrafish.
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KEYWORD
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Zebrafish, Diabetic complications, Diabetic retinopathy, Herbal medicines
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